Nicole Kidman - Isabel Bigelow / Samantha
Will Ferrell - Jack Wyatt / Darrin
Shirley MacLaine - Iris Smythson / Endora
Michael Caine - Nigel Bigelow
Jason Schwartzman - Ritchie
Kristin Chenoweth - Maria Kelly
Heather Burns - Nina
Jim Turner - Larry
Stephen Colbert - Stu Robison
David Alan Grier - Jim Fields
Michael Badalucco - Joey Props
Carole Shelley - Aunt Clara
Steve Carell - Uncle Arthur
Katie Finneran - Sheila Wyatt
James Lipton - Himself
Conan O'Brien - Himself
Amy Sedaris - Gladys Kravitz
Richard Kind - Abner Kravitz
Ken Hudson Campbell - Writer (as Ken Campbell)
P.J. Byrne - Writer
Carole Androsky - Realtor (as Carol Androsky)
Annie Mumolo - Bed, Bath and Beyond Shopper
Andrew Friedman - Bed, Bath and Beyond Shopper
Clay Bravo - Coffee Shop Waitress
Heather Freedman - Beverly Hills Hotel Hostess
Jonathan T. Floyd - Cable Man (as Jonathan Floyd)
Ed McMahon - Himself
Alison MacInnis - Auditioning Actress
Bridget Brno - Auditioning Actress (as Bridget Brno)
Dana Daurey - Auditioning Actress
Dorie Barton - Auditioning Actress
Katie Carroll - Auditioning Actress (as Katharine Carroll)
Jennifer Elise Cox - Auditioning Actress
Laura Sorenson - Auditioning Actress
Brittany Paige - Auditioning Actress
Dawn Ashley Cook - Auditioning Actress
Julia Schuler - Auditioning Actress
Abbey McBride - Auditioning Actress
Jennifer Hall - Book Soup Cafe Waitress
Roxanne Beckford - Francine
Hugh Davidson - Network Executive
Joe Zymblosky - Randall
J.J. Sacha - Voice-Over Announcer
Susan Chuang - Press Conference Reporter
Jordan Black - Press Conference Photographer
Mo Rocca - E! Reporter
Jason Winston George - E! Anchor (as Jason George)
Wendi McLendon-Covey - E! Anchor
Julie Claire - Hillary
Terry Savage - Dinner Party Guest
Dianne Dreyer - Production Staff Assistant
Kate Walsh - Sexy Waitress
Valerie Azlynn - Gorgeous Model
Jarrad Paul - Valet
Victor Williams - Police Officer
Liesel Staubitz - Trick-or-Treater
Ruby Rose Skotchdopole - Trick-or-Treater
Molly Gordon - Trick-or-Treater
Nick Lachey - Vietnam Soldier
Elizabeth Montgomery - Samantha Stephens (archive footage)
Todd Stashwick - Hall Smith (scenes deleted)
Dick York - Darrin Stephens (archive footage)
Stephen Cobos - Teen (uncredited)
Colleen Dunn - Dance Double (uncredited)
Meredith Giangrande - (uncredited)
Evan Grayson - Valet (uncredited)
Jennifer Haworth - Dinner Party Guest (uncredited)
Aj Katana - GRIP#1 (uncredited)
Chrissy May - Samantha Auditioner (uncredited)
Maria Nicotero - Auditioning Actress (uncredited)
Robert O'Connor - Party Guest 2 (uncredited)
Mina Olivera - Dinner Guest (uncredited)
Dan Ostermann - Dixieland Bandmember (uncredited)
Scott Alan Smith - Dinner Party Guest (uncredited)
Larry Sullivan - Dinner Party Guest (uncredited)
Sheila Thomas - Press Conference Reporter (uncredited)
Danielle Weeks - Auditioning actress (uncredited)